SCHEMBL27628136

SCHEMBL27628136

O=[PH](O)c1cccc(C2CCCCC2)c1C1CCCCC1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.39
CEL P19835 2/20 0.37
KMO O15229 1/20 0.36
PTGS2 P35354 1/20 0.35
ABCB1 P08183 2/20 0.34
PTPN5 P54829 3/20 0.33
HDAC4 P56524 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
PTPN2 P17706 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HTR1A P08908 1/20 0.32
HTR7 P34969 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29876519 0.85 CEL (0.36) PTGDR2CELKMOPTGS2ABCB1
SCHEMBL10844097 0.84 PTGDR2 (0.45) PTGDR2CELKMOPTGS2PTPN5
SCHEMBL780832 0.84 PTGDR2 (0.45) PTGDR2CELKMOPTGS2PTPN5
SCHEMBL239469 0.79 ABCB1 (0.43) PTGDR2CELKMOPTGS2ABCB1
SCHEMBL14353365 0.77 ABCB1 (0.42) PTGDR2CELKMOPTGS2ABCB1
SCHEMBL777873 0.77 CEL (0.41) PTGDR2CELPTGS2ABCB1HDAC4
SCHEMBL901458 0.74 CHRNB2 (0.53) PTGDR2CELKMOABCB1PTPN5
SCHEMBL4962002 0.74 CHRNB2 (0.53) PTGDR2CELKMOABCB1PTPN5
SCHEMBL4961639 0.74 CHRNB2 (0.53) PTGDR2CELKMOABCB1PTPN5
SCHEMBL4958023 0.74 CHRNB2 (0.53) PTGDR2CELKMOABCB1PTPN5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1745049-A Ligands for metals and improved metal-catalyzed processes based thereon MASSACHUSETTS INST TECHNOLOGY (US) 2006-03-08 CN disclosed