Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768960 | 0.84 | TP53 (0.51) | LMNATP53 | |
| SCHEMBL4191215 | 0.81 | HPGD (0.44) | SSTR4HPGDPDE4APDE4BPDE4D | |
| SCHEMBL8353152 | 0.81 | HPGD (0.44) | SSTR4HPGDPDE4APDE4BPDE4D | |
| SCHEMBL5840688 | 0.81 | HPGD (0.44) | SSTR4HPGDPDE4APDE4BPDE4D | |
| SCHEMBL5747378 | 0.81 | HPGDS (0.45) | SSTR4MCHR1OPRK1HPGDPDE4B | |
| SCHEMBL8352231 | 0.78 | HPGD (0.50) | MCHR1HPGDPDE4APDE4BPDE4D | |
| SCHEMBL27609552 | 0.78 | NPC1 (0.46) | OPRK1HPGDLMNA | |
| SCHEMBL3174715 | 0.78 | NPC1 (0.58) | OPRK1HPGDLMNA | |
| SCHEMBL8353042 | 0.77 | HPGD (0.51) | MCHR1HPGDPDE4APDE4BPDE4D | |
| SCHEMBL5778940 | 0.77 | HPGD (0.51) | HPGDPDE4APDE4BPDE4DIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1652782-A | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER (US) | 2005-08-10 | — | — | CN | disclosed |