Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27628874 | 0.83 | PTPN1 (0.37) | — | |
| SCHEMBL27628880 | 0.77 | PGR (0.32) | MEN1KMT2ANPSR1DRD2 | |
| SCHEMBL27606465 | 0.71 | P2RX4 (0.35) | ALDH1A1L3MBTL1 | |
| SCHEMBL28031070 | 0.70 | MEN1 (0.34) | MEN1KMT2ANPSR1ALDH1A1POLB | |
| SCHEMBL27841613 | 0.65 | ESR1 (0.36) | NPSR1ALDH1A1DRD2KDM4EHPGD | |
| SCHEMBL27790260 | 0.62 | CHRNB4 (0.33) | — | |
| SCHEMBL27859215 | 0.62 | MEN1 (0.34) | MEN1KMT2ANPSR1ALDH1A1TDP1 | |
| SCHEMBL10555306 | 0.60 | MEN1 (0.33) | MEN1KMT2ANPSR1 | |
| SCHEMBL340356 | 0.59 | KDM4E (0.44) | NPSR1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL637323 | 0.59 | CTNNB1 (0.55) | ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101503409-B | 8-(3-amino-piperidin-1-yl)-xanthines, the production thereof and the use of the same as medicaments | BOEHRINGER INGELHEIM PHARMA | 2014-01-22 | — | — | CN | disclosed |
| CN-101503408-B | 8-(3-amino-piperidin-1-yl)-xanthines | BEOEHRINGER INGELHEIM PHARMA GMBH & CO KG | 2013-04-24 | — | — | CN | disclosed |
| CN-101503408-A | 8-(3-amino-piperidin-1-yl)-xanthines | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101503409-A | 8-(3-amino-piperidin-1-yl)-xanthines, the production thereof and the use of the same as medicaments | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-100522962-C | 8- [ 3-amino-piperidin-1-yl ] -xanthines, process for their preparation and their use as pharmaceutical preparations | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-05 | — | — | CN | disclosed |
| CN-1675212-A | 8- [ 3-amino-piperidin-1-yl ] -xanthines, process for their preparation and their use as pharmaceutical preparations | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-28 | — | — | CN | disclosed |