Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.85 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.85 |
| ▸ | PGR | P06401 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | SHBG | P04278 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 1/20 | 0.85 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL6447755 | 0.93 | HIF1A (0.81) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL4932219 | 0.93 | HIF1A (0.81) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL3999007 | 0.92 | HIF1A (0.96) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL13202859 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL10292969 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL24900238 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL15114813 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL10261067 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL13046615 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 | |
| Hydrocortisone SCHEMBL6370134 | 0.92 | HIF1A (1.00) | NR3C1HIF1AHSD17B10CYP2C19NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112512528-A | Novel use of glucocorticoids for treating epithelial microbial infections of fluid-containing organs with natural exterior orifice in mammals | 维克公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-100366621-C | Plumepoppy total alkaloid salt and its prepn and application | CHANGSHA SHIWEI SCI TECH CO LT (CN) | 2008-02-06 | — | — | CN | disclosed |
| CN-1740175-A | Plumepoppy total alkaloid salt and its prepn and application | CHANGSHA SHIWEI SCI TECH CO LT (CN) | 2006-03-01 | — | — | CN | disclosed |