Hydrocortisone

SCHEMBL6447755

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.O=C(OOC(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.81

▸	HIF1A	Q16665	9/20	0.81

▸	NR3C2	P08235	4/20	0.81

▸	CYP2C19	P33261	2/20	0.81

▸	HSD17B10	Q99714	2/20	0.81

▸	PGR	P06401	2/20	0.81

▸	SERPINA6	P08185	2/20	0.81

▸	SMN1; SMN2	Q16637	2/20	0.81

▸	CYP3A4	P08684	2/20	0.81

▸	NFKB1	P19838	2/20	0.81

▸	KMT2A	Q03164	2/20	0.81

▸	SHBG	P04278	1/20	0.81

▸	MAPT	P10636	1/20	0.81

▸	LMNA	P02545	2/20	0.67

▸	AR	P10275	1/20	0.67

▸	CHRM1	P11229	1/20	0.67

▸	PMP22	Q01453	1/20	0.61

▸	TSHR	P16473	1/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Hydrocortisone SCHEMBL4932219	1.00	HIF1A (0.81)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL27628953	0.93	NR3C1 (0.85)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
SCHEMBL2472390	0.91	HIF1A (0.71)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
SCHEMBL18278997	0.90	HIF1A (0.80)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL3999007	0.90	HIF1A (0.96)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL24900238	0.90	HIF1A (1.00)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL10292969	0.90	HIF1A (1.00)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL13202859	0.90	HIF1A (1.00)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL13046615	0.90	HIF1A (1.00)	HIF1ANR3C1NR3C2CYP2C19HSD17B10
Hydrocortisone SCHEMBL15114813	0.90	HIF1A (1.00)	HIF1ANR3C1NR3C2CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1589945-A1	TOPICAL PHARMACEUTICAL AND/OR COSMETIC DISPENSE SYSTEMS	EDKO Trading and Representation Co., Ltd (TR)	2005-11-02	—	—	EP	disclosed
WO-2004064803-A1	TOPICAL PHARMACEUTICAL AND/OR COSMETIC DISPENSE SYSTEMS	EDKO TRADING AND REPRESENTATION CO. LTD (TR)	2004-08-05	—	—	WO	disclosed