Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 4/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420336 | 0.98 | HDAC1 (0.68) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL2634195 | 0.95 | HTR7 (0.66) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL18806577 | 0.91 | HDAC1 (0.56) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL4831377 | 0.90 | HTR7 (0.60) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL2764867 | 0.87 | MMP1 (0.62) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL13410667 | 0.86 | HTR7 (0.55) | HDAC1HDAC8HSD17B3HTR7MMP1 | |
| SCHEMBL18753070 | 0.85 | HSD17B3 (0.84) | HSD17B3HTR7STSMAPT | |
| SCHEMBL23049765 | 0.84 | HDAC1 (0.67) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL5849402 | 0.84 | HDAC1 (0.67) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL13085794 | 0.83 | HSD17B3 (0.85) | HSD17B3HTR7STSALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-101255170-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-09-03 | — | — | CN | disclosed |
| CN-101172981-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-05-07 | — | — | CN | disclosed |
| CN-100366624-C | 2, 3-dihydro-6-nitroimidazo [2,1-b ] * azole compounds | OTSUKA PHARMA CO LTD (JP) | 2008-02-06 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| CN-1705670-A | 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds | OTSUKA PHARMA CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |