Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112562 | 0.76 | BACE1 (0.44) | PTGS2DPP4PDCD1CD274KMT2A | |
| Hydrochloric Acid SCHEMBL27629774 | 0.76 | ESR2 (0.41) | PTGS2PDCD1CD274SMN1; SMN2CA1 | |
| SCHEMBL27747972 | 0.76 | PTGS2 (0.41) | PTGS2DPP4PDCD1CD274KMT2A | |
| Hydrochloric Acid SCHEMBL718400 | 0.75 | PTGS2 (0.35) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL29800393 | 0.72 | DPP4 (0.50) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL31124517 | 0.72 | DPP4 (0.50) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL1727355 | 0.72 | DPP4 (0.50) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL328862 | 0.72 | DPP4 (0.60) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL31261742 | 0.72 | DPP4 (0.60) | PTGS2DPP4PDCD1CD274KMT2A | |
| SCHEMBL28689603 | 0.72 | HDAC4 (0.48) | DPP4PDCD1CD274KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026293-A | fiber-reinforced polypropylene resin composition | 马自达汽车株式会社 | 2018-05-11 | — | — | CN | disclosed |
| CN-1689801-A | Biaxially oriented multi-layer film using propylene-ethylene random block copolymer as a surface layer | JAPAN POLYPROPYLENE CORP (JP) | 2005-11-02 | — | — | CN | disclosed |