SCHEMBL27630403

SCHEMBL27630403

Cc1cc(N(C)Cc2oc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.45
PPARG P37231 5/20 0.45
PPARA Q07869 4/20 0.45
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 2/20 0.40
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PTPN1 P18031 2/20 0.40
NR1H2 P55055 2/20 0.38
NR1H3 Q13133 2/20 0.38
IKBKB O14920 1/20 0.37
DHFR P00374 2/20 0.37
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
BACE1 P56817 1/20 0.37
CHUK O15111 1/20 0.37
TXNRD1 Q16881 1/20 0.37
NOX4 Q9NPH5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27650474 0.89 PPARD (0.47) PPARDPPARGPPARACYP1A2CYP2C19
SCHEMBL4854406 0.82 PPARD (0.70) PPARDPPARGPPARAPTPN1
SCHEMBL4853408 0.79 PPARD (0.61) PPARDPPARGPPARAPTPN1
SCHEMBL4852696 0.77 PPARD (0.49) PPARDPPARGPPARAKDM4EALDH1A1
SCHEMBL27650470 0.77 PPARD (0.69) PPARDPPARGPPARAALDH1A1MAPT
SCHEMBL27630406 0.74 PPARD (0.47) PPARDPPARGPPARAKDM4EALDH1A1
SCHEMBL4467452 0.74 PPARD (0.58) PPARDPPARGPPARACYP1A2CYP2C19
SCHEMBL27650643 0.73 PPARG (0.47) PPARDPPARGPPARAPTPN1IKBKB
SCHEMBL27642973 0.73 PPARD (0.42) PPARDPPARGPPARADHFRL3MBTL1
SCHEMBL27664118 0.73 PPARD (0.42) PPARDPPARGPPARAKDM4ENR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1809541-A Aniline derivatives HOFFMANN LA ROCHE (CH) 2006-07-26 CN claimed
CN-1809541-A Aniline derivatives HOFFMANN LA ROCHE (CH) 2006-07-26 CN disclosed