Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 7/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GRB2 | P62993 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469880 | 0.85 | FFAR2 (0.46) | FFAR2FPR2PPARGPPARAEPHX2 | |
| SCHEMBL1519730 | 0.85 | FFAR2 (0.46) | FFAR2FPR2PPARGPPARAEPHX2 | |
| SCHEMBL1742099 | 0.84 | FFAR2 (0.43) | FFAR2FPR2PPARGPPARAEPHX2 | |
| SCHEMBL12765909 | 0.83 | PPARG (0.50) | PPARGPPARA | |
| SCHEMBL1744255 | 0.82 | FFAR2 (0.42) | FFAR2FPR2PPARGPPARAEPHX2 | |
| SCHEMBL1519784 | 0.81 | EGFR (0.47) | FFAR2FPR2PPARGPPARAEPHX2 | |
| SCHEMBL21528813 | 0.78 | MMP2 (0.50) | FFAR2PPARGPPARAEPHX2FFAR1 | |
| SCHEMBL21528815 | 0.78 | MMP2 (0.50) | FFAR2PPARGPPARAEPHX2FFAR1 | |
| SCHEMBL1742102 | 0.74 | FFAR2 (0.40) | FFAR2FFAR1 | |
| SCHEMBL1519426 | 0.74 | PPARG (0.39) | FPR2PPARGPPARAEPHX2GRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173728-A2 | HETEROCYCLIC MODULATORS OF PKB | Amgen Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009011880-A2 | HETEROCYCLIC MODULATORS OF PKB | AMGEN INC. (US) | 2009-01-22 | — | — | WO | disclosed |