Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700537 | 0.85 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL31317689 | 0.85 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL700536 | 0.85 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL27615294 | 0.81 | — | — | |
| SCHEMBL9849735 | 0.81 | NFE2L2 (0.91) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL14401249 | 0.79 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL700304 | 0.79 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL27383008 | 0.79 | NFE2L2 (0.77) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL29446272 | 0.79 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 | |
| SCHEMBL700305 | 0.79 | NFE2L2 (1.00) | NFE2L2PTGS1PTGS2NQO2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1835928-A | Pyrimidone compounds as calcium-sensitive receptor antagonists | NPS PHARMA INC (US) | 2006-09-20 | — | — | CN | disclosed |