Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6459226 | 0.85 | MCHR1 (0.48) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6459221 | 0.85 | MCHR1 (0.48) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6874577 | 0.83 | LMNA (0.52) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6874583 | 0.83 | LMNA (0.52) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6465613 | 0.82 | MCHR1 (0.53) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6867655 | 0.81 | MCHR1 (0.48) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6867658 | 0.81 | MCHR1 (0.48) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6459228 | 0.81 | MCHR1 (0.52) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6930413 | 0.81 | MCHR1 (0.52) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6879865 | 0.81 | MCHR1 (0.57) | MCHR1NPY5RSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |