Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27632572 | 1.00 | DRD2 (0.39) | DRD2MCHR1ADRA2ASMYD3HTR1A | |
| SCHEMBL27652829 | 0.86 | ALDH1A1 (0.35) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL27652827 | 0.86 | ALDH1A1 (0.35) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL27632587 | 0.84 | MCHR1 (0.37) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27632588 | 0.84 | MCHR1 (0.37) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27653038 | 0.84 | MCHR1 (0.38) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27653039 | 0.84 | MCHR1 (0.38) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27652712 | 0.84 | MCHR1 (0.43) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27652714 | 0.84 | MCHR1 (0.43) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27631302 | 0.83 | MCHR1 (0.44) | MCHR1ADRA2AHTR1AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |