Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27653798 | 0.84 | HTR6 (0.60) | HTR6SLC16A3NR3C2ALDH1A1LMNA | |
| SCHEMBL27670927 | 0.81 | HTR6 (0.61) | HTR6ALDH1A1 | |
| SCHEMBL27659408 | 0.81 | HTR6 (0.61) | HTR6HCRTR1ALDH1A1 | |
| SCHEMBL27633279 | 0.80 | HTR6 (0.69) | HTR6HCRTR1KCNA5EDNRBEDNRA | |
| SCHEMBL337314 | 0.75 | HTR6 (1.00) | HTR6 | |
| SCHEMBL27650865 | 0.70 | HTR6 (0.48) | HTR6ALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL27653802 | 0.68 | ALDH1A1 (0.34) | ALDH1A1KDM4ECYP3A4HSD17B10GAA | |
| SCHEMBL3257769 | 0.67 | HCRTR1 (0.66) | HCRTR1SLC16A3RECQLALDH1A1GAA | |
| SCHEMBL6006634 | 0.66 | CYP3A4 (0.69) | HCRTR1ALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL20125139 | 0.65 | EDNRB (0.50) | HTR6HCRTR1KCNA5EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100518736-C | Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators | ESTEVE LABOR DR (ES) | 2009-07-29 | — | — | CN | claimed |
| CN-1829508-A | Indole-4 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators | ESTEVE LABOR DR (ES) | 2006-09-06 | — | — | CN | claimed |
| CN-100518736-C | Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators | ESTEVE LABOR DR (ES) | 2009-07-29 | — | — | CN | disclosed |
| CN-1829508-A | Indole-4 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators | ESTEVE LABOR DR (ES) | 2006-09-06 | — | — | CN | disclosed |