Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506919 | 0.82 | HDAC3 (0.53) | LOXL2CYP2D6HRH4HRH3NOS1 | |
| SCHEMBL2643707 | 0.81 | LOXL2 (0.62) | LOXL2ENPP2HTR2CCFDNOS1 | |
| Ethane SCHEMBL27753883 | 0.79 | LOXL2 (0.60) | LOXL2ENPP2HTR2CCFDNOS1 | |
| SCHEMBL13028737 | 0.79 | LOXL2 (0.60) | LOXL2ENPP2HTR2CACHECFD | |
| SCHEMBL6154661 | 0.79 | PBRM1 (0.50) | CYP2D6HRH4HRH3ACHEALDH1A1 | |
| SCHEMBL28201097 | 0.79 | LOXL2 (0.59) | LOXL2CYP2D6ENPP2HTR2CCFD | |
| SCHEMBL19370543 | 0.78 | LOXL2 (0.58) | LOXL2ENPP2HTR2CACHECFD | |
| SCHEMBL28879863 | 0.77 | LOXL2 (0.57) | LOXL2CYP2D6ENPP2HTR2CCFD | |
| SCHEMBL3506895 | 0.77 | CA12 (0.52) | CYP2D6HRH4HRH3ACHEALDH1A1 | |
| SCHEMBL28879968 | 0.77 | LOXL2 (0.57) | LOXL2CYP2D6ENPP2HTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688549-A | Compound having TGF-beta inhibitory activity and medicinal composition containing the same | KIRIN BREWERY (JP) | 2005-10-26 | — | — | CN | disclosed |