Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | FLT3 | P36888 | 6/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636370 | 0.89 | IKBKE (0.67) | IKBKEKITKDRFLT3ALOX5AP | |
| SCHEMBL6798531 | 0.88 | KDR (0.59) | IKBKEKITKDRFLT3CSF1R | |
| SCHEMBL27657320 | 0.88 | KDR (0.51) | IKBKEKITKDRFLT3ALOX5AP | |
| SCHEMBL27636455 | 0.88 | KIT (0.53) | IKBKEKITKDRFLT3CSF1R | |
| SCHEMBL27657354 | 0.88 | KDR (0.51) | IKBKEKITKDRFLT3ALOX5AP | |
| SCHEMBL27657311 | 0.86 | KDR (0.56) | IKBKEKITKDRFLT3ALOX5AP | |
| SCHEMBL14953303 | 0.85 | KDR (0.49) | IKBKEKITKDRFLT3SCN9A | |
| SCHEMBL420675 | 0.82 | IKBKE (0.81) | IKBKEKITKDRFLT3CSF1R | |
| SCHEMBL425369 | 0.82 | KDR (0.49) | IKBKEKITKDRFLT3CSF1R | |
| SCHEMBL5257214 | 0.81 | KDR (0.51) | IKBKEKITKDRFLT3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |