Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798531 | 0.90 | KDR (0.59) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL27636455 | 0.90 | KIT (0.53) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL27657320 | 0.90 | KDR (0.51) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL27636397 | 0.88 | IKBKE (0.62) | KDRFLT3KITIKBKEMET | |
| SCHEMBL27636562 | 0.87 | KDR (0.56) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL14953303 | 0.87 | KDR (0.49) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL27657441 | 0.86 | KDR (0.57) | KDRFLT3KITIKBKENCF1 | |
| SCHEMBL27636410 | 0.81 | KDR (0.45) | KDRFLT3KITMETINSR | |
| SCHEMBL28760587 | 0.79 | KDR (0.44) | KDRFLT3KITNCF1LMNA | |
| SCHEMBL27636370 | 0.79 | IKBKE (0.67) | KDRFLT3KITIKBKEALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |