Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.59 |
| ▸ | FLT3 | P36888 | 10/20 | 0.59 |
| ▸ | KIT | P10721 | 10/20 | 0.59 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636455 | 0.90 | KIT (0.53) | KDRFLT3KITIKBKETEK | |
| SCHEMBL27657320 | 0.90 | KDR (0.51) | KDRFLT3KITIKBKEINSR | |
| SCHEMBL27657354 | 0.90 | KDR (0.51) | KDRFLT3KITIKBKEINSR | |
| SCHEMBL27636397 | 0.88 | IKBKE (0.62) | KDRFLT3KITIKBKETEK | |
| SCHEMBL14953303 | 0.88 | KDR (0.49) | KDRFLT3KITIKBKETEK | |
| SCHEMBL420989 | 0.81 | KDR (0.78) | KDRFLT3KITIKBKETEK | |
| SCHEMBL27636370 | 0.80 | IKBKE (0.67) | KDRFLT3KITIKBKETEK | |
| SCHEMBL27636562 | 0.80 | KDR (0.56) | KDRFLT3KITIKBKETEK | |
| SCHEMBL423319 | 0.77 | KDR (0.78) | KDRFLT3KITIKBKETEK | |
| SCHEMBL423279 | 0.76 | KIT (0.57) | KDRFLT3KITIKBKENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABL1, MAP3K19, MAP3K1 | KDR 800/4885FLT3 41/4885KIT 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.