Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 8/20 | 0.53 |
| ▸ | BCR | P11274 | 8/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.52 |
| ▸ | SGK1 | O00141 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399494 | 0.88 | KDR (0.54) | JAK2ABL1BCRPDPK1SGK1 | |
| SCHEMBL27636557 | 0.86 | FGFR2 (0.51) | JAK2ABL1BCRPDPK1SGK1 | |
| SCHEMBL27657351 | 0.85 | KDR (0.61) | JAK2ABL1BCRPDPK1SGK1 | |
| SCHEMBL12907241 | 0.80 | JAK2 (1.00) | JAK2PDPK1SGK1AURKAAURKB | |
| SCHEMBL3361070 | 0.80 | JAK2 (1.00) | JAK2PDPK1SGK1AURKAAURKB | |
| SCHEMBL27657352 | 0.80 | KDR (0.66) | JAK2ABL1BCRAURKAAURKB | |
| SCHEMBL27657316 | 0.77 | KDR (0.55) | JAK2ABL1BCRAURKAAURKB | |
| SCHEMBL27657295 | 0.77 | KDR (0.55) | JAK2ABL1BCRPDPK1SGK1 | |
| SCHEMBL12907256 | 0.76 | JAK2 (0.69) | JAK2ABL1BCRPDPK1SGK1 | |
| SCHEMBL423903 | 0.75 | KDR (0.73) | JAK2ABL1PDPK1SGK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |