Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 8/20 | 0.50 |
| ▸ | BCR | P11274 | 8/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636404 | 0.88 | JAK2 (0.65) | KDRABL1BCRJAK2PDPK1 | |
| SCHEMBL27636557 | 0.85 | FGFR2 (0.51) | KDRABL1BCRJAK2PDPK1 | |
| SCHEMBL4739562 | 0.85 | KDR (0.74) | KDRABL1BCRJAK2AURKA | |
| SCHEMBL27657351 | 0.84 | KDR (0.61) | KDRABL1BCRJAK2PDPK1 | |
| SCHEMBL4491663 | 0.78 | PDPK1 (0.71) | KDRABL1BCRJAK2PDPK1 | |
| SCHEMBL4606083 | 0.74 | PARP1 (0.52) | JAK2 | |
| SCHEMBL423310 | 0.74 | KDR (0.73) | KDRABL1JAK2AURKAAURKB | |
| SCHEMBL366746 | 0.73 | PARP1 (0.47) | JAK2 | |
| SCHEMBL6479941 | 0.73 | JAK2 (0.72) | KDRABL1BCRJAK2PDPK1 | |
| SCHEMBL4739859 | 0.72 | KDR (0.63) | KDRABL1BCRJAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |