Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 7/20 | 0.48 |
| ▸ | BCR | P11274 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636404 | 0.86 | JAK2 (0.65) | ABL1BCRJAK2PDPK1SGK1 | |
| SCHEMBL27657331 | 0.86 | KDR (0.43) | FGFR2FGFR3FGFR1ABL1BCR | |
| SCHEMBL27636462 | 0.85 | KDR (0.60) | FGFR1ABL1BCRJAK2MKNK2 | |
| SCHEMBL3399494 | 0.85 | KDR (0.54) | FGFR1ABL1BCRJAK2PDPK1 | |
| SCHEMBL27657295 | 0.82 | KDR (0.55) | FGFR2FGFR3FGFR1ABL1BCR | |
| SCHEMBL27657396 | 0.82 | KDR (0.52) | FGFR2FGFR3FGFR1ABL1BCR | |
| SCHEMBL27636379 | 0.82 | KDR (0.48) | FGFR2FGFR3FGFR1ABL1BCR | |
| SCHEMBL27657351 | 0.82 | KDR (0.61) | ABL1BCRJAK2PDPK1SGK1 | |
| SCHEMBL27636419 | 0.81 | KDR (0.52) | FGFR1ABL1BCRJAK2KDR | |
| SCHEMBL27657333 | 0.78 | KDR (0.54) | FGFR2FGFR3FGFR1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |