Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648611 | 1.00 | CTSS (0.39) | CTSSCTSKKMT2ASMN1; SMN2SLC7A5 | |
| SCHEMBL8704232 | 1.00 | CTSS (0.39) | CTSSCTSKKMT2ASMN1; SMN2SLC7A5 | |
| SCHEMBL469053 | 0.88 | CTSS (0.42) | CTSSCTSKKMT2ASMN1; SMN2SLC7A5 | |
| SCHEMBL1952090 | 0.88 | CTSS (0.42) | CTSSCTSKKMT2ASMN1; SMN2SLC7A5 | |
| SCHEMBL1573827 | 0.88 | CTSS (0.42) | CTSSCTSKKMT2ASMN1; SMN2SLC7A5 | |
| SCHEMBL27616098 | 0.87 | MIF (0.34) | CTSSCTSKMAPT | |
| SCHEMBL27602308 | 0.86 | CYP2C9 (0.41) | KMT2AGABBR2GABBR1ATM | |
| SCHEMBL27658710 | 0.86 | ALDH1A1 (0.37) | CTSSCTSKMAPTALDH1A1 | |
| SCHEMBL27644324 | 0.86 | CYP2C9 (0.41) | KMT2AGABBR2GABBR1ATM | |
| SCHEMBL27616093 | 0.86 | ALDH1A1 (0.37) | CTSSCTSKMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1759118-B | Diazepinoindole derivatives as kinase inhibitors | PFIZER | 2010-12-08 | — | — | CN | disclosed |
| CN-1759118-A | Diazepinoindole derivatives as kinase inhibitors | PFIZER (US) | 2006-04-12 | — | — | CN | disclosed |