Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 1/20 | 0.52 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572292 | 0.77 | ALOX5 (0.47) | GAPDHALOX5PTGS2PTGS1CYP3A4 | |
| SCHEMBL14919902 | 0.77 | AR (0.51) | MAP2K4GAPDHALOX5CLK1CLK2 | |
| Hydrochloric Acid SCHEMBL6782247 | 0.76 | ALOX5 (0.46) | GAPDHALOX5PTGS2PTGS1CYP3A4 | |
| SCHEMBL1753671 | 0.75 | PTGDR2 (0.65) | — | |
| SCHEMBL27466656 | 0.74 | BCL2L1 (0.59) | GAPDHALOX5PTGS2PTGS1CYP3A4 | |
| SCHEMBL13247899 | 0.74 | MAP2K4 (0.52) | MAP2K4PTGS2PTGS1CLK1CLK2 | |
| SCHEMBL27541697 | 0.74 | KIF11 (0.61) | MAP2K4ALOX5KMT2AALDH1A1MEN1 | |
| SCHEMBL5098907 | 0.73 | BCL2L1 (0.52) | GAPDHALOX5KMT2AALDH1A1MEN1 | |
| SCHEMBL17141676 | 0.73 | NTRK1 (0.45) | KMT2AALDH1A1MEN1CYP1A2CYP2C19 | |
| SCHEMBL15675199 | 0.72 | BIRC5 (0.44) | AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | claimed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | claimed |
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | disclosed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | disclosed |