Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048495 | 0.93 | HTR2A (0.59) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL777971 | 0.84 | MAPT (0.56) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL7541817 | 0.84 | HTR2A (0.56) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL11120903 | 0.83 | HTR2A (0.51) | HTR2AKCNH2HTR2CMAPTALDH1A1 | |
| SCHEMBL776544 | 0.83 | HTR2A (0.51) | HTR2AKCNH2HTR2CMAPTCCR6 | |
| SCHEMBL16863988 | 0.83 | HTR2A (0.56) | HTR2AKCNH2HTR2CMAPTALDH1A1 | |
| SCHEMBL776895 | 0.83 | MAPT (0.55) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL17803 | 0.79 | HTR2A (0.51) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL2100232 | 0.79 | HTR2A (0.51) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| Hydrochloric Acid SCHEMBL1021139 | 0.78 | HTR2A (0.50) | HTR2AKCNH2HTR2CMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1751042-B | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD | 2011-02-23 | — | — | CN | disclosed |
| CN-1751042-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2006-03-22 | — | — | CN | disclosed |