Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639681 | 0.87 | KIF11 (0.50) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL30241803 | 0.79 | KIF11 (0.53) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL27639725 | 0.79 | KCNN4 (0.64) | KIF11KCNH2LMNACHRM2CYP2D6 | |
| SCHEMBL2319756 | 0.79 | KMT2A (0.54) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL5060670 | 0.78 | KIF11 (0.50) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL17964412 | 0.76 | KIF11 (0.70) | KIF11KCNH2LMNA | |
| SCHEMBL28305536 | 0.76 | KIF11 (0.49) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL17833432 | 0.75 | KCNN4 (0.54) | KIF11KCNH2CES2CES1NPC1 | |
| SCHEMBL29882115 | 0.75 | CHRM3 (0.50) | KCNH2CES1LMNACHRM2CYP2D6 | |
| SCHEMBL31404235 | 0.74 | KIF11 (0.50) | KIF11KCNH2CES2CES1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101790374-A | Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted | LUNDBECK & CO AS H | 2010-07-28 | — | — | CN | claimed |
| CN-101378742-B | Use of KCNQ-openers for the preparation of a pharmaceutical composition for the treatment of schizophrenia | LUNDBECK & CO AS H | 2013-07-10 | — | — | CN | disclosed |
| CN-101790374-A | Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted | LUNDBECK & CO AS H | 2010-07-28 | — | — | CN | disclosed |
| CN-1761464-A | Substituted p-diaminobenzene derivatives | LUNDBECK & CO AS H (DK) | 2006-04-19 | — | — | CN | disclosed |