Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2764355 | 1.00 | ACACB (0.38) | ACACBPTPN11CA1CA2CA4 | |
| SCHEMBL19962270 | 0.73 | CYP2C9 (0.48) | TRPA1 | |
| SCHEMBL30277283 | 0.73 | CYP2C9 (0.48) | TRPA1 | |
| SCHEMBL31059808 | 0.72 | AAK1 (0.41) | IRAK4TRPA1 | |
| SCHEMBL31059517 | 0.72 | AAK1 (0.41) | IRAK4TRPA1 | |
| SCHEMBL1519761 | 0.70 | ATM (0.40) | — | |
| SCHEMBL1519764 | 0.70 | ATM (0.40) | — | |
| SCHEMBL1741864 | 0.70 | GPR139 (0.40) | CA1CA2CA4CA7CA9 | |
| SCHEMBL15925954 | 0.69 | AAK1 (0.45) | DGAT1TRPA1 | |
| SCHEMBL16088906 | 0.69 | LGMN (0.41) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173728-A2 | HETEROCYCLIC MODULATORS OF PKB | Amgen Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009011880-A2 | HETEROCYCLIC MODULATORS OF PKB | AMGEN INC. (US) | 2009-01-22 | — | — | WO | disclosed |