Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.69 |
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 11/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27662120 | 0.90 | EGFR (0.70) | EGFRKDRRETKIF5BCSF1R | |
| SCHEMBL27641654 | 0.90 | EGFR (0.64) | EGFRKDRRETKIF5BCSF1R | |
| SCHEMBL30846509 | 0.82 | EGFR (1.00) | EGFRKDRRETKIF5BCSF1R | |
| SCHEMBL5864878 | 0.72 | PDE10A (0.65) | EGFRKDRPDGFRBERBB2SRC | |
| SCHEMBL27477737 | 0.70 | CSF1R (0.60) | EGFRKDRRETKIF5BCSF1R | |
| SCHEMBL2257706 | 0.70 | CSF1R (1.00) | EGFRKDRRETKIF5BCSF1R | |
| SCHEMBL7513340 | 0.70 | KDR (0.52) | EGFRKDRPDGFRBERBB2SRC | |
| SCHEMBL27662119 | 0.69 | EGFR (0.54) | EGFRKDRCSF1RPDGFRBERBB2 | |
| SCHEMBL3574998 | 0.69 | CSF1R (0.56) | EGFRKDRRETKIF5BCSF1R | |
| Hydrochloric Acid SCHEMBL6179746 | 0.69 | CSF1R (1.00) | EGFRKDRRETKIF5BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1854130-B | Chinazoline derivative, its production, medicinal composition and use | INST MATERIA MEDICA CAMS | 2011-04-20 | — | — | CN | claimed |
| CN-1854130-A | Chinazoline derivative, its production, medicinal composition and use | PHARMACEUTICAL INST CHINA ACAD (CN) | 2006-11-01 | — | — | CN | claimed |
| CN-1854130-B | Chinazoline derivative, its production, medicinal composition and use | INST MATERIA MEDICA CAMS | 2011-04-20 | — | — | CN | disclosed |
| CN-1854130-A | Chinazoline derivative, its production, medicinal composition and use | PHARMACEUTICAL INST CHINA ACAD (CN) | 2006-11-01 | — | — | CN | disclosed |