Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 10/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512908 | 0.76 | LMNA (0.49) | KDM4EMAPTMAPK1ABCG2 | |
| SCHEMBL5864878 | 0.72 | PDE10A (0.65) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL7780495 | 0.71 | EGFR (0.54) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL7773688 | 0.71 | EGFR (0.54) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL7778261 | 0.71 | EGFR (0.54) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL5824553 | 0.70 | KDR (0.71) | KDREGFRSRCMAPK14KIT | |
| SCHEMBL7780507 | 0.70 | EGFR (0.69) | KDREGFRERBB2KDM4EMAPK1 | |
| SCHEMBL27641671 | 0.70 | EGFR (0.69) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL2125179 | 0.69 | EGFR (0.61) | KDREGFRERBB2SRCFBP1 | |
| SCHEMBL9423 | 0.69 | EGFR (1.00) | KDREGFRERBB2SRCFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6103728-A | MODULATING TYROSINE SIGNAL TRANSDUCTION TO PREVENT AND TREAT CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES; ANTICARCINOGENIC,-TUMOR, PROLIFERATIVE AGENTS | SUGEN, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0832073-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | Sugen, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040648-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |