Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | CCR9 | P51686 | 11/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532008 | 0.90 | LMNA (0.71) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL28642 | 0.87 | LMNA (0.74) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL2530753 | 0.86 | CCR9 (0.74) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL28006 | 0.85 | LMNA (0.86) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL12221183 | 0.85 | LMNA (0.73) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL27982 | 0.85 | LMNA (0.77) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL27979 | 0.84 | LMNA (0.83) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL5120002 | 0.82 | SLC10A6 (0.62) | CCR9KMT2AKCNA5SLC10A6 | |
| SCHEMBL12242366 | 0.82 | LMNA (0.80) | LMNAHTTCCR9MAPTTP53 | |
| SCHEMBL28518 | 0.82 | LMNA (0.80) | LMNAHTTCCR9MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100582091-C | Bis-aryl sulfonamides | CHEMOCENTRYX | 2010-01-20 | — | — | CN | disclosed |
| CN-1738796-A | Bis-aryl sulfonamides | CHEMOCENTRYX (US) | 2006-02-22 | — | — | CN | disclosed |