Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL28366860 | 0.90 | ALDH1A1 (0.58) | TSHRNR4A2KEAP1ALDH1A1CES2 | |
| Chlorobenzene SCHEMBL27839339 | 0.89 | NR4A2 (0.47) | TSHRNR4A2KEAP1ALDH1A1CYP2C19 | |
| Chlorobenzene SCHEMBL10599624 | 0.87 | NR4A2 (0.45) | TSHRNR4A2KEAP1ALDH1A1CYP2C19 | |
| Chlorobenzene SCHEMBL28695795 | 0.86 | TSHR (0.48) | TSHRNR4A2KEAP1ALDH1A1CYP2C19 | |
| Chlorobenzene SCHEMBL28208301 | 0.86 | HDAC3 (0.56) | TSHRNR4A2KEAP1ALDH1A1CES2 | |
| Chlorobenzene SCHEMBL28030555 | 0.84 | HDAC3 (0.54) | TSHRNR4A2KEAP1ALDH1A1CES2 | |
| Chlorobenzene SCHEMBL27740841 | 0.84 | HDAC3 (0.54) | TSHRNR4A2KEAP1ALDH1A1CES2 | |
| Chlorobenzene SCHEMBL3005502 | 0.84 | TSHR (0.58) | TSHRKEAP1ALDH1A1CES2CES1 | |
| Chlorobenzene SCHEMBL29172530 | 0.83 | TSHR (0.73) | TSHRALDH1A1CES2CES1KMT2A | |
| Chlorobenzene SCHEMBL2533883 | 0.83 | TSHR (0.73) | TSHRALDH1A1CES2CES1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100503571-C | Tetrahydro isoquinoline derivative and its preparation process and medicine use | UNIV CHINA PHARMA (CN) | 2009-06-24 | — | — | CN | disclosed |
| CN-1887872-A | Tetrahydro isoquinoline derivative and its prepn process and medicine use | UNIV CHINA PHARMACY (CN) | 2007-01-03 | — | — | CN | disclosed |