Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27643151 | 0.84 | TSHR (0.58) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL27620795 | 0.83 | TSHR (0.73) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL2533883 | 0.83 | TSHR (0.73) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL29172530 | 0.83 | TSHR (0.73) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL27677153 | 0.82 | TSHR (0.55) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL6906848 | 0.82 | TSHR (0.55) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL27339919 | 0.82 | TSHR (0.55) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL27460518 | 0.82 | TSHR (0.55) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL28280446 | 0.81 | TSHR (0.61) | TSHRCES2CES1L3MBTL1MAPT | |
| Chlorobenzene SCHEMBL16894006 | 0.80 | TSHR (0.69) | TSHRCES2CES1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981094-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-03-17 | — | — | US | disclosed |
| EP-2152270-B1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-04 | — | — | EP | disclosed |
| CN-101854907-B | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid | SEDERMA SA | 2014-06-18 | — | — | CN | disclosed |
| CN-102802601-A | Cosmetic use of tyr-arg dipeptide to combat cutaneous sagging | SEDERMA SA | 2012-11-28 | — | — | CN | disclosed |
| CN-101854907-A | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid | SEDERMA SA | 2010-10-06 | — | — | CN | disclosed |
| US-20100190789-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-07-29 | — | — | US | disclosed |
| EP-2152270-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008148868-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-11 | — | — | WO | disclosed |
| CN-1802918-A | Plant growth regulation | ROHM & HAAS (US) | 2006-07-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190789-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | NR2C2, NR5A2, DGAT1 | TSHR 2379/4885CES2 301/4885CES1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.