Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.74 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.74 |
| ▸ | IKBKB | O14920 | 3/20 | 0.66 |
| ▸ | PLK1 | P53350 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021033 | 0.88 | AURKA (0.62) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL7470875 | 0.85 | PLK1 (0.63) | PIK3CAPIK3CBPIK3CGPLK1SYK | |
| SCHEMBL4735987 | 0.85 | PIK3CA (0.68) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL4062045 | 0.83 | CAMK2D (0.78) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL4735460 | 0.83 | PLK1 (0.82) | PIK3CAPIK3CBPIK3CGPLK1MEN1 | |
| SCHEMBL4070306 | 0.82 | MAPK8 (0.77) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL13049909 | 0.82 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL4376505 | 0.82 | JAK2 (0.79) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL4736128 | 0.82 | PIK3CG (0.76) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 | |
| SCHEMBL14021028 | 0.81 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGIKBKBPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1860104-A | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LTD (GB) | 2006-11-08 | — | — | CN | claimed |