Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | BCR | P11274 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643199 | 0.85 | PIK3CA (0.74) | PLK1CAMK2DSYKAURKAVCP | |
| SCHEMBL7467852 | 0.84 | PIK3CA (0.65) | CAMK2DSYKABL1BCRSRC | |
| SCHEMBL7470313 | 0.84 | ABL1 (0.58) | CAMK2DABL1BCRSRCPIK3CA | |
| SCHEMBL4903317 | 0.84 | ABL1 (0.70) | PLK1CAMK2DAURKAABL1BCR | |
| SCHEMBL4029958 | 0.84 | ABL1 (0.72) | CAMK2DAURKAABL1BCRSRC | |
| SCHEMBL7464205 | 0.84 | ABL1 (0.76) | PLK1SYKABL1BCRSRC | |
| SCHEMBL13911480 | 0.84 | CAMK2D (0.68) | PLK1CAMK2DAURKAABL1BCR | |
| SCHEMBL27115894 | 0.83 | CAMK2D (0.60) | PLK1CAMK2DSYKABL1BCR | |
| SCHEMBL7472770 | 0.83 | ABL1 (0.67) | PLK1CAMK2DABL1BCRSRC | |
| SCHEMBL7464657 | 0.82 | CAMK2D (0.90) | CAMK2DAURKAABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |