Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.55 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HMBS | P08397 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28280408 | 0.83 | HMBS (0.48) | ERCC1ERCC4ACHEHMBSALDH1A1 | |
| SCHEMBL28240618 | 0.79 | NPC1 (0.47) | ERCC1ERCC4HMBSALDH1A1POLB | |
| SCHEMBL1126714 | 0.78 | AURKA (0.50) | TNKS2HMBSALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28250640 | 0.77 | ERCC1 (0.52) | ERCC1ERCC4TNKS2MAPK14NR4A2 | |
| SCHEMBL28294910 | 0.74 | HMBS (0.39) | ERCC1ERCC4HMBSTDO2 | |
| SCHEMBL197346 | 0.72 | BCL2L1 (0.55) | ACHEPOLBSMN1; SMN2MAPTBCL2L1 | |
| SCHEMBL10337645 | 0.72 | BCL2L1 (0.55) | ACHEPOLBSMN1; SMN2MAPTBCL2L1 | |
| SCHEMBL12562793 | 0.72 | BCL2L1 (0.55) | ACHEPOLBSMN1; SMN2MAPTBCL2L1 | |
| SCHEMBL10300262 | 0.72 | BCL2L1 (0.55) | ACHEPOLBSMN1; SMN2MAPTBCL2L1 | |
| SCHEMBL26821699 | 0.72 | BCL2L1 (0.55) | ACHEPOLBSMN1; SMN2MAPTBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100349895-C | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2007-11-21 | — | — | CN | disclosed |
| CN-1759117-A | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2006-04-12 | — | — | CN | disclosed |