Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602067 | 0.84 | MAPT (0.67) | MAPTALDH1A1ERN1KDM4EHPGD | |
| SCHEMBL5532236 | 0.81 | ALDH1A1 (0.74) | MAPTALDH1A1HTR2BKDM4EHPGD | |
| SCHEMBL11263632 | 0.78 | ACHE (0.44) | MAPTALDH1A1HDAC3HDAC1HDAC7 | |
| SCHEMBL27995668 | 0.77 | EGFR (0.60) | ALDH1A1HDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL9832453 | 0.76 | KDM4E (0.46) | ALDH1A1HDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL2766900 | 0.76 | HDAC3 (0.45) | MAPTALDH1A1HDAC3HDAC1HDAC7 | |
| SCHEMBL2766904 | 0.76 | HDAC3 (0.45) | MAPTALDH1A1HDAC3HDAC1HDAC7 | |
| SCHEMBL4600962 | 0.75 | ALDH1A1 (0.72) | ALDH1A1HDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL18003043 | 0.74 | MAPT (0.58) | MAPTALDH1A1HTR2BKDM4EHPGD | |
| SCHEMBL13815761 | 0.74 | HTR2B (0.60) | MAPTALDH1A1ERN1HTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104610230-A | Compounds for the treatment of cancer | UNIV TENNESSEE RES FOUNDATION | 2015-05-13 | — | — | CN | disclosed |
| CN-102137592-B | Compounds for the treatment of cancer | UNIV TENNESSEE RES FOUNDATION (US) | 2015-01-28 | — | — | CN | disclosed |
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |