Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079753 | 0.87 | LTA4H (0.42) | CYP2C19KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL27644605 | 0.79 | LTA4H (0.39) | CYP2D6KMT2AMEN1NFKB1LMNA | |
| SCHEMBL390626 | 0.77 | CYP3A4 (0.43) | POLBCYP2C9CYP2C19CYP2D6KMT2A | |
| SCHEMBL27514296 | 0.77 | CYP3A4 (0.43) | POLBCYP2C9CYP2C19CYP2D6KMT2A | |
| SCHEMBL1147794 | 0.77 | CYP3A4 (0.43) | POLBCYP2C9CYP2C19CYP2D6KMT2A | |
| SCHEMBL27400981 | 0.76 | POLB (0.56) | POLBCYP2C9CYP2C19CYP2D6KMT2A | |
| SCHEMBL7319980 | 0.76 | GRM2 (0.49) | LTA4HSLC7A5GRIK1 | |
| SCHEMBL2795228 | 0.76 | KMT2A (0.43) | CYP2C9CYP2C19CYP2D6KMT2AMEN1 | |
| SCHEMBL9544124 | 0.76 | GRM2 (0.49) | LTA4HSLC7A5GRIK1 | |
| SCHEMBL25320423 | 0.76 | CYP3A4 (0.55) | CYP2C9CYP2C19CYP2D6CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882347-A | AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2006-12-20 | — | — | CN | disclosed |