Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | CFD | P00746 | 5/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540046 | 0.88 | TAAR1 (0.61) | LOXL2TAAR1HRH3CSNK2A1 | |
| SCHEMBL233049 | 0.87 | — | — | |
| SCHEMBL3791745 | 0.87 | LOXL2 (0.60) | PNMTENPP2LOXL2TAAR1CFD | |
| SCHEMBL27452333 | 0.86 | TAAR1 (0.54) | PNMTENPP2LOXL2TAAR1CFD | |
| SCHEMBL27871127 | 0.85 | LOXL2 (0.52) | PNMTENPP2LOXL2TAAR1NOS3 | |
| SCHEMBL43554 | 0.80 | TAAR1 (0.70) | PNMTENPP2LOXL2TAAR1CFD | |
| SCHEMBL3794460 | 0.80 | TAAR1 (0.70) | PNMTENPP2LOXL2TAAR1CFD | |
| SCHEMBL29400616 | 0.80 | TAAR1 (0.70) | PNMTENPP2LOXL2TAAR1CFD | |
| SCHEMBL5990622 | 0.79 | PRKCI (0.58) | ENPP2CDK8FGFR1 | |
| Bromide SCHEMBL1856525 | 0.78 | TAAR1 (0.67) | PNMTENPP2LOXL2TAAR1CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| CN-1311779-A | Succinoylamino lactams as inhibitors and as A beta protein production | DU PONT PHARM CO (US) | 2001-09-05 | — | — | CN | disclosed |