Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617250 | 0.86 | NR1D1 (0.46) | MAPTRAB9AALDH1A1POLB | |
| SCHEMBL27645508 | 0.84 | KCNH2 (0.45) | KCNH2TSHRSIGMAR1 | |
| SCHEMBL27897920 | 0.83 | ATM (0.47) | KCNH2MAPTRAB9AALDH1A1KMT2A | |
| SCHEMBL3534499 | 0.82 | KCNH2 (0.53) | KCNH2TSHRMAPTRAB9ABMP1 | |
| SCHEMBL16682343 | 0.80 | KCNH2 (0.56) | KCNH2TSHRMAPTRAB9ABMP1 | |
| SCHEMBL992030 | 0.76 | KCNH2 (0.50) | KCNH2TSHRMAPTALDH1A1KMT2A | |
| SCHEMBL21461681 | 0.74 | KCNH2 (0.53) | KCNH2TSHRMAPTRAB9ABMP1 | |
| SCHEMBL16682344 | 0.74 | KCNH2 (0.53) | KCNH2TSHRALDH1A1KMT2ACDC25C | |
| SCHEMBL10720687 | 0.73 | ALDH1A1 (0.54) | KCNH2TSHRMAPTRAB9AALDH1A1 | |
| SCHEMBL19491362 | 0.73 | KCNH2 (0.52) | KCNH2TSHRMAPTBMP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882586-A | 1H-imidazo[4,5-C]quinoline derivatives in the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2006-12-20 | — | — | CN | disclosed |