Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 8/20 | 0.85 |
| ▸ | MAPT | P10636 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 4/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.85 |
| ▸ | HTT | P42858 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 2/20 | 0.85 |
| ▸ | RECQL | P46063 | 2/20 | 0.85 |
| ▸ | BLM | P54132 | 2/20 | 0.85 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.85 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.64 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL20239317 | 0.99 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL4235133 | 0.99 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL2361033 | 0.99 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL6231484 | 0.97 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL28442968 | 0.95 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL384697 | 0.94 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL27157739 | 0.93 | FTO (0.92) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL264013 | 0.93 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL7966195 | 0.93 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL8462127 | 0.93 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100569286-C | Attenuated strains of Vibrio cholerae having improved biosafety characteristics in lyophilized form for oral vaccination | CNIC CT NAC INVESTIGACIONES (CU) | 2009-12-16 | — | — | CN | disclosed |
| CN-1780640-A | Attenuated strain of Vibrio cholerae with improved biosafety characteristics in lyophilized form for oral vaccination | CNIC CT NAC INVESTIGACIONES (CU) | 2006-05-31 | — | — | CN | disclosed |