Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420325 | 0.73 | SLC6A9 (0.73) | SLC6A9SLC6A5ENPP2LMNAMAPT | |
| SCHEMBL4427344 | 0.72 | SLC6A9 (0.66) | SLC6A9SLC6A5ENPP2KCNH2LMNA | |
| SCHEMBL31349271 | 0.72 | ALDH1A1 (0.50) | SLC6A9SLC6A5MGLLENPP2MAPT | |
| SCHEMBL5038044 | 0.72 | SLC6A9 (0.65) | SLC6A9SLC6A5KDM4EMGLLENPP2 | |
| SCHEMBL4425899 | 0.72 | SLC6A9 (0.72) | SLC6A9SLC6A5ENPP2KCNH2LMNA | |
| SCHEMBL5132304 | 0.72 | SLC6A9 (0.61) | SLC6A9SLC6A5ENPP2KCNH2LMNA | |
| SCHEMBL31349221 | 0.71 | SLC6A9 (0.52) | SLC6A9SLC6A5MGLLENPP2MAPT | |
| SCHEMBL4420914 | 0.71 | SLC6A9 (0.66) | SLC6A9SLC6A5ENPP2KCNH2LMNA | |
| SCHEMBL4422175 | 0.70 | SLC6A9 (0.62) | SLC6A9SLC6A5MGLLENPP2KCNH2 | |
| SCHEMBL4425815 | 0.70 | SLC6A9 (0.62) | SLC6A9SLC6A5MGLLENPP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1867554-B | Piperazine with ortho-substituted phenyl and its use as GLYT1 inhibitors | HOFFMANN LA ROCHE | 2011-07-06 | — | — | CN | disclosed |
| CN-1867554-A | Piperazine with ortho-substituted phenyl and its use as GLYT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2006-11-22 | — | — | CN | disclosed |