Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27649622 | 0.87 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL27649498 | 0.81 | FYN (0.49) | ALDH1A1EPHB4PTGS2FYNPTGS1 | |
| SCHEMBL19270949 | 0.81 | FYN (0.49) | ALDH1A1EPHB4PTGS2FYNPTGS1 | |
| SCHEMBL27649562 | 0.79 | TSHR (0.45) | FYNMAPT | |
| SCHEMBL25338172 | 0.71 | PTGS2 (0.59) | PTGS2PTGS1MAPT | |
| SCHEMBL7607312 | 0.70 | FYN (0.51) | ALDH1A1EPHB4PTGS2FYNPTGS1 | |
| SCHEMBL693823 | 0.70 | FYN (0.44) | ALDH1A1EPHB4PTGS2FYNPTGS1 | |
| SCHEMBL4825442 | 0.70 | PTGS2 (0.45) | ALDH1A1EPHB4PTGS2FYNPTGS1 | |
| SCHEMBL4829637 | 0.69 | KDM4E (0.53) | PTGS2FYNPTGS1 | |
| SCHEMBL6368263 | 0.68 | PTGS2 (0.56) | ALDH1A1PTGS2FYNPTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |