Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871137 | 0.89 | TSHR (0.47) | SMN1; SMN2TSHRCYP19A1ALDH1A1HPGD | |
| Succinic Acid SCHEMBL21385162 | 0.81 | KDR (0.53) | TSHRCYP19A1ALDH1A1MAPTEGFR | |
| SCHEMBL6467224 | 0.78 | EGFR (0.43) | SMN1; SMN2CYP19A1ALDH1A1TDP1CYP1A2 | |
| SCHEMBL17241010 | 0.75 | CYP1A2 (0.49) | SMN1; SMN2CYP19A1ALDH1A1ALOX15CYP1A2 | |
| SCHEMBL1814398 | 0.74 | TDP1 (0.47) | SMN1; SMN2CYP19A1ALDH1A1HPGDTDP1 | |
| Water SCHEMBL27524611 | 0.73 | TDP1 (0.46) | SMN1; SMN2CYP19A1ALDH1A1HPGDTDP1 | |
| SCHEMBL7069713 | 0.71 | CYP19A1 (0.61) | SMN1; SMN2CYP19A1ALDH1A1HPGDTDP1 | |
| SCHEMBL31738482 | 0.71 | CYP19A1 (0.61) | SMN1; SMN2CYP19A1ALDH1A1HPGDTDP1 | |
| Succinic Acid SCHEMBL5599499 | 0.70 | KDR (0.72) | SMN1; SMN2RAB9AEGFRKDRKMT2A | |
| Hydralazine SCHEMBL28421512 | 0.69 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1TDP1ADORA3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1791396-A | Combination of histone deacetylase inhibitors with chemotherapeutic agents | NOVARTIS AG (CH) | 2006-06-21 | — | — | CN | claimed |
| CN-1791396-A | Combination of histone deacetylase inhibitors with chemotherapeutic agents | NOVARTIS AG (CH) | 2006-06-21 | — | — | CN | disclosed |