Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 2/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631875 | 0.88 | MGMT (0.42) | MAPTMAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL1673998 | 0.83 | GPR119 (0.62) | MAPTKDM4EALDH1A1GPR119MEN1 | |
| SCHEMBL1673601 | 0.82 | AURKA (0.51) | KDM4EALDH1A1GAAMETGPR119 | |
| SCHEMBL27652097 | 0.80 | ATM (0.42) | MAOBMAOAMGMTRBP4GPR119 | |
| SCHEMBL27652247 | 0.78 | SERPINE1 (0.49) | GPR119 | |
| SCHEMBL1673935 | 0.75 | GPR119 (0.61) | MAPTKDM4EALDH1A1GPR119MEN1 | |
| SCHEMBL46749 | 0.73 | SERPINE1 (0.41) | MAPTMAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL1673623 | 0.71 | GPR119 (0.64) | MAPTKDM4EALDH1A1GPR119MEN1 | |
| SCHEMBL1673949 | 0.71 | HTT (0.48) | ALDH1A1METRPS6KB1 | |
| SCHEMBL12733443 | 0.70 | GPR119 (0.64) | MAPTKDM4EALDH1A1GPR119MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1835943-A | 1,2, 3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prevention and treatment of diseases related thereto, such as diabetes and hyperglycemia | ARENA PHARM INC (US) | 2006-09-20 | — | — | CN | disclosed |