Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673935 | 0.90 | GPR119 (0.61) | GPR119 | |
| SCHEMBL27652088 | 0.82 | SERPINE1 (0.50) | SERPINE1GPR119POLBCYP2C9CYP2C19 | |
| SCHEMBL1673998 | 0.81 | GPR119 (0.62) | GPR119 | |
| SCHEMBL27652250 | 0.79 | GPR119 (0.60) | SERPINE1GPR119POLBCYP2C9CYP2C19 | |
| SCHEMBL12733479 | 0.78 | GPR119 (0.62) | GPR119POLB | |
| SCHEMBL27652113 | 0.78 | MAPT (0.45) | GPR119 | |
| SCHEMBL27652222 | 0.76 | GPR119 (0.53) | SERPINE1GPR119POLBCYP2C9CYP2C19 | |
| SCHEMBL1673692 | 0.75 | GPR119 (0.70) | GPR119 | |
| SCHEMBL1673671 | 0.74 | GPR119 (0.61) | GPR119 | |
| SCHEMBL27631857 | 0.74 | GPR119 (0.62) | GPR119NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1835943-A | 1,2, 3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prevention and treatment of diseases related thereto, such as diabetes and hyperglycemia | ARENA PHARM INC (US) | 2006-09-20 | — | — | CN | disclosed |