SCHEMBL27653183

SCHEMBL27653183

Cc1cc(N)c2c(c1-c1ccc(O)cc1)c1ccccc1n2C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.47
KDM4E B2RXH2 3/20 0.46
MAPT P10636 1/20 0.46
ALKBH5 Q6P6C2 1/20 0.40
FTO Q9C0B1 1/20 0.40
CDK4 P11802 2/20 0.38
CCND1 P24385 2/20 0.38
CCNE2 O96020 1/20 0.38
PRKACA P17612 1/20 0.38
PRKACG P22612 1/20 0.38
PRKACB P22694 1/20 0.38
CCNE1 P24864 1/20 0.38
CDK2 P24941 1/20 0.38
LMNA P02545 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PKM P14618 1/20 0.38
LIMK1 P53667 2/20 0.38
PABPC1 P11940 1/20 0.37
NQO2 P16083 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27653184 0.82 KDM4E (0.46) RETKDM4EMAPTALKBH5FTO
SCHEMBL27046198 0.82 RET (0.57) RETKDM4EMAPTALKBH5FTO
SCHEMBL3879102 0.81 KDM4E (0.53) RETKDM4EMAPTALKBH5FTO
SCHEMBL3877123 0.78 KDM4E (0.56) KDM4EMAPTALKBH5FTOCDK4
SCHEMBL27673143 0.77 RET (0.60) RETKDM4EMAPTALKBH5FTO
SCHEMBL27673100 0.77 RET (0.56) RETKDM4EMAPTALKBH5FTO
SCHEMBL27653075 0.77 RET (0.46) RETKDM4EMAPTALKBH5FTO
SCHEMBL27673140 0.76 HSP90AA1 (0.46) RETKDM4EMAPTALKBH5FTO
SCHEMBL27653158 0.76 RET (0.45) RETKDM4EMAPTLMNAKMT2A
SCHEMBL27653076 0.73 RET (0.45) RETKDM4EMAPTLMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1937994-A Keratin dyeing compounds, keratin dyeing compositions containing them and their use PROCTER & GAMBLE (US) 2007-03-28 CN disclosed