Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28759635 | 0.88 | RIPK2 (0.43) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL27674485 | 0.88 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4060209 | 0.87 | HSD17B10 (0.46) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4059500 | 0.86 | JAK2 (0.43) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4051848 | 0.85 | TP53 (0.52) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL1652258 | 0.81 | PDE4B (0.48) | LOXL2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4051093 | 0.79 | LMNA (0.51) | PDE4BTP53LMNASMN1; SMN2GABRP | |
| SCHEMBL4050910 | 0.78 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL27674487 | 0.78 | LOXL2 (0.48) | LOXL2LMNAFGFR1CDK8CDK5 | |
| SCHEMBL27654535 | 0.77 | PDE4A (0.39) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878759-A | Pyridazin-3 (2H) -one derivatives and their use as PDE4 inhibitors | ALMIRALL PRODESFARMA SA (ES) | 2006-12-13 | — | — | CN | disclosed |