Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634833 | 0.88 | ATR (0.42) | ATRCNR1ACVR1EGLN1MAPT | |
| SCHEMBL4680498 | 0.85 | HTT (0.48) | HTTCNR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27634832 | 0.75 | ACVR1 (0.50) | CNR1ACVR1CNR2 | |
| SCHEMBL27634894 | 0.75 | CNR2 (0.41) | ATRCNR1ACVR1MAPTNPC1 | |
| SCHEMBL28759848 | 0.75 | CNR1 (0.53) | ATRCNR1ACVR1CNR2 | |
| SCHEMBL4679252 | 0.73 | HTT (0.44) | HTTCNR1MAPTKMT2ATAS1R3 | |
| SCHEMBL4678614 | 0.72 | CNR1 (0.44) | CNR1MAPTCNR2ATMMAPK1 | |
| SCHEMBL27635023 | 0.71 | ATR (0.49) | ATRCNR1ACVR1CNR2 | |
| SCHEMBL4682587 | 0.70 | HTT (0.55) | HTTCNR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5463864 | 0.68 | PHGDH (0.45) | MAPK1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | claimed |
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |