Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | AHR | P35869 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655845 | 0.88 | HTT (0.44) | ATRACVR1CNR2CNR1TRPA1 | |
| SCHEMBL4678614 | 0.85 | CNR1 (0.44) | GABRA5AHRCNR2CNR1MAPT | |
| SCHEMBL27635023 | 0.85 | ATR (0.49) | ATRGABRA5AHRACVR1SYK | |
| SCHEMBL28759848 | 0.77 | CNR1 (0.53) | ATRACVR1CNR2CNR1 | |
| SCHEMBL27634894 | 0.77 | CNR2 (0.41) | ATRACVR1CNR2CNR1MAPT | |
| SCHEMBL27634832 | 0.75 | ACVR1 (0.50) | ACVR1CNR2CNR1 | |
| SCHEMBL5463864 | 0.72 | PHGDH (0.45) | MAPK1 | |
| SCHEMBL4680498 | 0.72 | HTT (0.48) | CNR2CNR1 | |
| SCHEMBL5463818 | 0.70 | CNR1 (0.42) | CNR2CNR1 | |
| SCHEMBL5754645 | 0.69 | GABRA5 (0.43) | GABRA5ACVR1CNR2CNR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | claimed |
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |