Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656146 | 1.00 | KDM4E (0.44) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL5358564 | 0.84 | NR4A1 (0.53) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL28032410 | 0.82 | KDM4E (0.52) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL5358558 | 0.81 | KDM4E (0.50) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL18663455 | 0.80 | KDM4E (0.46) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL8230482 | 0.80 | PIM1 (0.50) | KDM4EGPR3ALDH1A1MEN1KMT2A | |
| SCHEMBL30075099 | 0.78 | KDM4E (0.50) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL27546968 | 0.77 | KDM4E (0.46) | KDM4EGPR3NR4A1NR4A2NR4A3 | |
| SCHEMBL3862098 | 0.74 | LIG1 (0.46) | KDM4EGPR3MGAMALDH1A1HPGD | |
| SCHEMBL28177676 | 0.72 | NR4A1 (0.53) | KDM4EGPR3NR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104817534-A | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | ALTANA PHARMA AG | 2015-08-05 | — | — | CN | disclosed |
| CN-104803974-A | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | TAKEDA GMBH | 2015-07-29 | — | — | CN | disclosed |
| CN-104803973-A | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors | TAKEDA GMBH | 2015-07-29 | — | — | CN | disclosed |
| CN-104761545-A | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | TAKEDA GMBH | 2015-07-08 | — | — | CN | disclosed |
| CN-102295634-A | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors | — | 2011-12-28 | — | — | CN | disclosed |
| CN-1922170-A | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 | ALTANA PHARMA AG (DE) | 2007-02-28 | — | — | CN | disclosed |