Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GPR3 | P46089 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 10/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032410 | 0.87 | KDM4E (0.52) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL5358564 | 0.86 | NR4A1 (0.53) | KDM4EGPR3ALDH1A1PARP1MEN1 | |
| SCHEMBL5358558 | 0.86 | KDM4E (0.50) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL27546968 | 0.82 | KDM4E (0.46) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL18663455 | 0.82 | KDM4E (0.46) | KDM4EGPR3ALDH1A1GAAMEN1 | |
| SCHEMBL27656146 | 0.80 | KDM4E (0.44) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL27656141 | 0.80 | KDM4E (0.44) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL30075099 | 0.79 | KDM4E (0.50) | PIM1KDM4EGPR3ALDH1A1MEN1 | |
| SCHEMBL3862098 | 0.79 | LIG1 (0.46) | KDM4EGPR3ALDH1A1GAAMEN1 | |
| SCHEMBL30350943 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1GAAPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422685-A | A kind of synthetic method of N- acetyl group phenanthridines -6- amide and its derivative | 浙江工业大学 | 2019-03-05 | — | — | CN | disclosed |
| EP-0642343-B1 | Acridine carboxamides for the treatment of cancer | XENOVA LTD (GB) | 2000-08-30 | — | — | EP | disclosed |
| US-5891886-A | PREVENTION DRUG RESISTANCE; ADMINISTERING N-(2-(DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| US-5783699-A | MAY BE CONJUGATED TO ANTIGENS, HAPTENS, ANTIBODIES IN IMMUNOASSAYS | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| US-5696131-A | ADMINISTERING N-(2-(DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE WITH OTHER ANTICANCER DRUGS IN A DIVIDED-DOSE SCHEDULE | XENOVA LIMITED (GB) | 1997-12-09 | — | — | US | disclosed |
| EP-0642343-A1 | TREATMENT OF CANCERS | XENOVA LIMITED (GB) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024096-A2 | USE OF N-(2-(DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE AND ITS ANALOGUES FOR CANCER TREATMENT | XENOVA LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |