Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086725 | 0.84 | HDAC8 (0.53) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL8801364 | 0.83 | ALDH1A1 (0.52) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL5425304 | 0.80 | HDAC8 (0.56) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL31335187 | 0.80 | HDAC8 (0.56) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL31335083 | 0.79 | NR1H4 (0.50) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL6086636 | 0.75 | IDO1 (0.53) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL7548794 | 0.75 | ALDH1A1 (0.60) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL27657235 | 0.75 | KMT2A (0.49) | PPARGSMN1; SMN2ALDH1A1MAOBMAOA | |
| SCHEMBL2767840 | 0.75 | HDAC8 (0.57) | HDAC8HDAC6HDAC11HDAC3HDAC1 | |
| SCHEMBL1122365 | 0.74 | NPC1 (0.54) | ALDH1A1HTTHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882537-A | Substituted indolecarboxylic acid derivatives and their use as PAI-1 inhibitors | WYETH CORP (US) | 2006-12-20 | — | — | CN | disclosed |